Studies on lysergic acid diethylamide and related compounds. V. Syntheses of dihydrolysergic acid diethylamides and related compounds.

Studies on Uric Acid and Related Compounds

The systematic study of the substrate specificity of mammalian xanthine oxidase has indicated a common mechanism by which various purines may be dehydrogenated (1). The results obtained also made it clear why methylated xanthines, with the exception of 1-methylxanthine (2), cannot be oxidized by xanthine oxidase to the corresponding substituted uric acids (3, 4). Therefore, another source had t...

Pteroylglutamic acid and related compounds.

Lysergic Acid Diethylamide and Psilocybin Revisited.

The past decade brought the beginnings of a renaissance in research on psychedelic drugs. Two articles in this issue of Biological Psychiatry signify that the resurrection of this longignored topic has begun to mature and bear at least the promise of fruit. In the early 1970s, the onset of the “War on Drugs” brought with it a near-total hiatus in serious research on psychedelic drugs, especiall...

Lysergic acid diethylamide: side effects and complications.

Acid hydrolysis of colchicine and related compounds.

Acid-catalyzed hydrolysis of the methox-ytropone moiety of colchicine has been shown to proceed at a greater rate than in the case of isocolchicine1. (Struc­ tures are shown in Table I.) No interpretation of this rate difference has been offered. And, while a mecha­ nism for the acid-catalyzed hydrolysis of 2 -methoxytropone has been proposed2, no kinetic data on this type of reaction either fo...